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Effects of MgO‐CaO‐P 2 O 5 ‐Na 2 O‐based additives on mechanical and biological properties of hydroxyapatite
Author(s) -
Kalita S. J.,
Rokusek D.,
Bose S.,
Hosick H. L.,
Bandyopadhyay A.
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30118
Subject(s) - materials science , diffractometer , sintering , biocompatibility , ceramic , indentation hardness , vickers hardness test , chemical engineering , phase (matter) , biocompatible material , nuclear chemistry , composite material , microstructure , metallurgy , biomedical engineering , scanning electron microscope , organic chemistry , medicine , engineering , chemistry
In this research, we improved densification, hardness, and compression strength of synthetic hydroxyapatite (HAp) ceramics by introducing small quantities of MgO‐CaO‐P 2 O 5 ‐Na 2 O‐based sintering additives. Biological properties of HAp were not altered by this procedure. Phase analyses were performed by using a Philips Xpert fully automated diffractometer with Co K‐alpha radiation to understand the influence of additives on phase purity in the final products. All compositions were characterized at green and sintered densities to understand the influence of additives on densification. Some of the compositions showed >40% increase in Vickers microhardness compared with pure HAp processed under the same conditions. Improvement in compression strength was also detected in some compositions. In vitro biological testing used a modified human osteoblast cell line to test biocompatibility, cell attachment, and cell proliferation. All these compositions were nontoxic and biocompatible. Our results indicate that MgO‐CaO‐P 2 O 5 ‐Na 2 O‐based sintering additives can be used to improve both mechanical and biological properties of HAp ceramics. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 35–44, 2004