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Effective accumulation of poly(vinylpyrrolidone‐ co ‐vinyl laurate) into the spleen
Author(s) -
Yoshioka Yasuo,
Tsutsumi Yasuo,
Mukai Yohei,
Shibata Hiroko,
Okamoto Takayuki,
Kaneda Yoshihisa,
Tsunoda Shinichi,
Kamada Haruhiko,
Koizumi Keiichi,
Yamamoto Yoko,
Mu Yu,
Kodaira Hiroshi,
SatoKamada Keiko,
Nakagawa Shinsaku,
Mayumi Tadanori
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30059
Subject(s) - polyvinylpyrrolidone , drug carrier , spleen , polymer , materials science , drug delivery , polymer chemistry , n vinylpyrrolidone , chemistry , nuclear chemistry , copolymer , nanotechnology , organic chemistry , medicine , immunology
To optimize polymer‐conjugated drugs as a polymeric drug delivery system, it is essential to design polymeric carriers with tissue‐specific targeting capacity. Previously, we showed that polyvinylpyrrolidone (PVP) was the most suitable polymeric carrier for prolonging the blood‐residency of drugs, and was one of the best parent polymers to design the polymeric carriers with targeting capacity. In this study, we synthesized some hydrophobic PVP derivatives, poly(vinylpyrrolidone‐ co ‐styrene) [poly(VP‐ co ‐S)] and poly(vinylpyrrolidone‐ co ‐vinyl laurate) [poly(VP‐ co ‐VL)], and assessed their biopharmaceutical properties after intravenous administration in mice. The elimination of hydrophobic PVP derivatives from blood was the same as PVP, and the plasma half‐lives of poly(VP‐ co ‐S) were almost similar to that of poly(VP‐ co ‐VL). Poly(VP‐ co ‐VL) efficiently accumulated in the spleen, whereas poly(VP‐ co ‐S) effectively accumulated in the liver. The level of poly(VP‐ co ‐VL) in the spleen was about 20 times higher than PVP and poly(VP‐ co ‐S). These hydrophobic PVP derivatives did not show any cytotoxicity against endothelial cells in vitro . Thus, poly(VP‐ co ‐VL) may be a useful polymeric carrier for drug delivery to the spleen. This study will provide useful information to design optimal polymeric carriers with targeting capacity to the spleen and liver. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 70A: 219–223, 2004