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Osteoblast responses to tape‐cast and sintered bioactive glass ceramics
Author(s) -
Gough J. E.,
Clupper D. C.,
Hench L. L.
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.30024
Subject(s) - materials science , ceramic , composite material , bioactive glass
The advantage of tape‐cast bioactive glasses lies in the manufacturing procedure, which allows the build‐up of layers and, therefore, the production of complex shapes. This, therefore, has applications to tissue engineering, where specific shapes are required such as repair of craniofacial defects. The bioactivity of tape‐cast discs sintered at temperatures ranging from 800°C to 1000°C and for 3 or 6 h was analyzed by FTIR. Tape‐cast discs were used to culture primary human osteoblasts, and cell attachment, cell death, collagen production, nodule formation, and mineralization were studied. These responses were dependent upon Si and Na release profiles of the tape‐cast discs, and development of the hydroxyapatite layer. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 69A: 621–628, 2004