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Macroporous poly(ϵ‐caprolactone) with antimicrobial activity obtained by iodine polymerization
Author(s) -
de Arruda Almeida Kleber,
de Queiroz Alvaro Antonio Alencar,
Higa Olga Zazuco,
Abraham Gustavo Abel,
San Román Julio
Publication year - 2003
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.20085
Subject(s) - antimicrobial , materials science , gel permeation chromatography , nuclear chemistry , iodophor , chinese hamster ovary cell , staphylococcus aureus , caprolactone , chromatography , microbiology and biotechnology , polymerization , bacteria , organic chemistry , chemistry , biochemistry , biology , composite material , polymer , receptor , genetics
The most serious problem usually encountered in the field of implanted biomedical devices is infectious morbidity as a primary source of mortality. In this work, the synthesis and characterization of a macroporous iodine‐based sanitizer (iodophor), poly(caprolactone)‐iodine (PCL‐I 2 ), are presented. Characterization methods include nuclear magnetic resonance spectroscopy, gel permeation chromatography, nitrogen adsorption‐desorption, and scanning electron microscopy. The in vitro cytotoxicity to CHO cells based on cell viability with Chinese hamster ovary cells (CHO) and antimicrobial activities against Escherichia coli and Staphylococcus aureus were examined . The obtained macropore PCL‐I 2 structures had a rather narrow size distribution. The PCL‐I 2 iodophor was noncytotoxic to Chinese hamster ovary cells. The antimicrobial activities of the PCL‐I 2 were assessed against E. coli and S. aureus. The tested PCL‐I 2 showed better antimicrobial activity against E. coli than against S. aureus . © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 473–478, 2004