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Responsive and recognitive hydrogels using star polymers
Author(s) -
Oral Ebru,
Peppas Nicholas A.
Publication year - 2004
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.20076
Subject(s) - materials science , self healing hydrogels , polymer , star (game theory) , chemical engineering , polymer science , nanotechnology , biomedical engineering , composite material , polymer chemistry , medicine , mathematical analysis , mathematics , engineering
Polymeric networks that have inherent capabilities to recognize different molecules and chemical changes in their environment are the next generation of materials that will aid in the diagnosis and treatment of diseases. We have prepared new networks based on star polymers that were designed to be responsive and recognitive. Using molecular imprinting with D‐glucose and crosslinking with poly(ethylene glycol) dimethacrylate with an ethylene glycol chain of nominal molecular weight 600, we prepared star polymer networks, which exhibited over 300% more uptake for D‐glucose compared to D‐fructose. Using copolymerization with methacrylic acid, we prepared star polymer networks with pH‐sensitivity, which showed a sharp transition in swelling around a pH of 4.5. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 439–447, 2004