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Novel bioactive and biodegradable glass ceramics with high mechanical strength in the CaOSiO 2 B 2 O 3 system
Author(s) -
Ryu HyunSeung,
Lee JungKun,
Seo JunHyuk,
Kim Hwan,
Hong Kug Sun,
Kim Deug Joong,
Lee Jae Hyup,
Lee DongHo,
Chang BongSoon,
Lee ChoonKi,
Chung SungSoo
Publication year - 2003
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.20029
Subject(s) - borosilicate glass , materials science , simulated body fluid , ceramic , apatite , wollastonite , composite material , fluorapatite , calcium aluminosilicate , chemical engineering , flexural strength , solubility , glass ceramic , microstructure , mineralogy , aluminosilicate , scanning electron microscope , chemistry , organic chemistry , engineering , catalysis , raw material
Novel bioactive and biodegradable glass ceramics with high mechanical strength in the (50‐ x /2)CaO · SiO 2 x B 2 O 3 (4.2 ≤ x ≤ 17.2) system were investigated. The systems consisted of three phases: monoclinic wollastonite, calcium metaborate, and amorphous borosilicate matrix. The glass ceramics containing 4.2 mol% and 8.4 mol% B 2 O 3 showed high bulk density and a dense microstructure. Mechanical strengths of the glass ceramics were higher than those of other bioactive ceramics: high compressive strength (2813 MPa), bending strength of 212 MPa, and fracture toughness of 3.12 MPa · m 1/2 . The glass‐ceramic formed apatite layer on their surface in the simulated body fluid and showed significant biodegradation. The degree of apatite formation in the glass ceramics depended on the calcium metaborate content and borosilicate glassy matrix. Additional calcium metaborate and borosilicate glassy matrix increased the apatite formation rate on the surface. It might be likely that calcium metaborate causes supersaturation of Ca ions, for its high solubility in SBF and the water‐reactive borosilicate glassy matrix formed SiOH groups on the surface to provide nucleation sites for apatite formation. Also, through in vitro test for the biocompatibility of the CaOSiO 2 B 2 O 3 glass ceramics, no cytotoxicity of the glass ceramics were found. The results on bioactivity and noncytotoxicity indicated that glass ceramics in the (50‐ x /2)CaO · SiO 2 x B 2 O 3 (4.2 ≤ x ≤ 17.2) system could be useful as a biodegradable bone replacement material. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 79–89, 2004