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In vivo degradation characteristics of poly(glycerol sebacate)
Author(s) -
Wang Yadong,
Kim Yu Mi,
Langer Robert
Publication year - 2003
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.10534
Subject(s) - materials science , sebacic acid , degradation (telecommunications) , glycerol , polymer , elastomer , composite material , biodegradable polymer , in vivo , swelling , chemical engineering , polymer chemistry , organic chemistry , chemistry , telecommunications , microbiology and biotechnology , computer science , engineering , biology
Abstract We have developed a series of biodegradable elastomers, poly(glycerol sebacate) (PGS), based on glycerol and sebacic acid. The polymers are potentially useful in soft tissue regeneration and engineering. To evaluate the performance of PGS in a physiological environment, we compared their degradation profiles with poly(DL‐lactide‐ co ‐glycolide) (50:50, carboxyl ended, M w 15,000) in vivo . Among the parameters examined are changes in weight and mechanical strength with time, implant geometry, surface characteristics, and degree of swelling. Unlike poly(DL‐lactide‐ co ‐glycolide), PGS primarily degrades by surface erosion, which gives a linear degradation profile of mass, preservation of geometry and intact surface, and retention of mechanical strength. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 66A: 192–197, 2003