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Dissolution properties of calcium phosphate granules with different compositions in simulated body fluid
Author(s) -
Monteiro Magna Maria,
da Rocha Nilce Carbonel Campos,
Rossi Alexandre Malta,
de Almeida Soares Gloria
Publication year - 2003
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.10479
Subject(s) - simulated body fluid , apatite , octacalcium phosphate , dissolution , calcination , materials science , calcium , scanning electron microscope , precipitation , chemical engineering , phosphate , fourier transform infrared spectroscopy , granule (geology) , mineralogy , nuclear chemistry , chemistry , metallurgy , composite material , biochemistry , physics , meteorology , engineering , catalysis
Calcium phosphate granules were produced through the calcination of three hydroxyapatites (HAs) at 1150°C: nearly‐stoichiometric (NS‐HA), calcium‐deficient (CD‐HA), and carbonated (Carb‐HA). The characterization using scanning electron microscope (SEM), X‐ray diffraction (XRD), and Fourier‐transformed infrared spectroscopy (FT‐IR) showed that those granules exhibit strong differences in chemical composition, surface texture, and dissolution behavior. Sample dissolution in a simulated body fluid (SBF) and precipitation of a calcium phosphate layer on the granule surface were followed up for 7 days by chemical analysis of calcium content in SBF. After 80‐min reaction, precipitation of new calcium phosphate phases predominates over the dissolution of original granules. Comparison between SEM images and XRD/FT‐IR analysis revealed that the composition of the calcium phosphate layer and its precipitation rate depend on the HA composition and its heat treatment. Calcined carbonated apatite induces the precipitation of an octacalcium phosphate (OPC) layer, whereas a carbonated apatite layer is formed from calcined‐deficient HA. The calcined nearly‐stoichiometric HA exhibits low efficiency in producing carbonated apatite layer. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 65A: 299–305, 2003