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Aggregation behaviors and their pH sensitivity of cholesterol‐conjugated proteinoids composed of glutamic acid and aspartic acid matrix
Author(s) -
Bae Soo Kyoung,
Kim JongDuk
Publication year - 2002
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.10336
Subject(s) - conjugated system , aspartic acid , glutamic acid , fourier transform infrared spectroscopy , amino acid , organic chemistry , chemistry , resonance (particle physics) , anhydrous , polymer chemistry , materials science , polymer , chemical engineering , biochemistry , physics , particle physics , engineering
Cholesterol‐conjugated proteinoids and their aggregation behaviors were investigated with model proteinoid systems. Model proteinoids of molecular weights in the range of 4000 to 6000 were synthesized by anhydrous thermal condensation forming a matrix with glutamic acid and aspartic acid and of naturally occurring amino acids. Nuclear magnetic resonance and Fourier transform infrared spectra suggested that cholesterol was conjugated to carboxyl group–forming pendants. Native water‐soluble proteinoids can form microspheres in acidified or heated conditions, but the cholesterol‐conjugated proteinoids were found to form aggregates in water, regardless of the temperature or pH of the solutions. The hydrophobic pendant moieties come to a compact association in core, whereas the hydrophilic chains provide a shield layer. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 64A: 282–290, 2003