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Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes
Author(s) -
Kobayashi Koichi,
Komatsu Teruyuki,
Iwamaru Arifumi,
Matsukawa Yasuko,
Horinouchi Hirohisa,
Watanabe Masazumi,
Tsuchida Eishun
Publication year - 2002
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.10323
Subject(s) - oxygen tension , hypoxia (environmental) , albumin , human serum albumin , recombinant dna , oxygenation , aorta , ascites , solid tumor , chemistry , oxygen , pharmacology , biology , medicine , biochemistry , cancer , organic chemistry , gene
Recombinant human serum albumin incorporating synthetic heme (rHSA‐FeP) was tested for its ability to increase O 2 tension in the hypoxia of the solid tumor rat model. By the direct administration of the rHSA‐FeP solution (10 mL/kg) via the aorta descendens to the ascites hepatoma LY80 tumor on the right femur, the O 2 tension of the hypoxic region immediately increased to 3.45 ± 1.43 Torr, which corresponds to a 2.4‐fold increase compared to that of the baseline value. These high O 2 levels continued for 300 s after the infusion. The rHSA‐FeP solution can be utilized not only as a red blood cell substitute but also as an O 2 ‐carrying medicine for the effective reoxygenation of the hypoxia solid tumor. © 2002 Wiley Periodicals Inc. J Biomed Mater Res 64A: 48–51, 2003
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