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Preparation and characterization of macroporous chitosan–gelatin/β‐tricalcium phosphate composite scaffolds for bone tissue engineering
Author(s) -
Yin Yuji,
Ye Fen,
Cui Junfeng,
Zhang Fujiang,
Li Xiulan,
Yao Kangde
Publication year - 2003
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.10153
Subject(s) - materials science , gelatin , chitosan , biocompatibility , composite number , glutaraldehyde , scanning electron microscope , scaffold , compressive strength , composite material , tissue engineering , fourier transform infrared spectroscopy , diffractometer , biomedical engineering , chemical engineering , chromatography , chemistry , organic chemistry , medicine , engineering , metallurgy
A biodegradable composite scaffold was developed using β‐tricalcium phosphate (β‐TCP) with chitosan (CS) and gelatin (Gel) in the form of a hybrid polymer network (HPN) via co‐crosslinking with glutaraldehyde. Various types of scaffolds were prepared by freezing and lyophilizing. These scaffolds were characterized by Fourier transform infrared, X‐ray diffractometer, and scanning electron microscopy. The macroporous composite scaffolds exhibited different pore structures. Compressive properties were improved, especially compressive modulus from 3.9–10.9 MPa. Biocompatibility was evaluated subcutaneously on rabbits. A mild inflammatory response was observed over 12 weeks. The results suggest that the scaffolds can be utilized in nonloading bone regeneration. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 844–855, 2003