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Author(s) -
Rodewald Marko,
Bae Hyeonsoo,
Huschke Sophie,
MeyerZedler Tobias,
Schmitt Michael,
Press Adrian Tibor,
Schubert Stephanie,
Bauer Michael,
Popp Juergen
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202170018
Subject(s) - hepatic stellate cell , liver fibrosis , cover (algebra) , pathology , medicine , biology , microbiology and biotechnology , fibrosis , engineering , mechanical engineering
Hepatic stellate cells (HSCs) are the key cell type in the development of liver fibrosis. Despite their importance, the identification of HSCs in bulky tissue has remained challenging. Coherent anti‐ Stokes Raman scattering microscopy (CARS) can be used to identify HSCs in the liver of a living mouse. HSCs are the main target of novel nanomedical strategies in the development of a treatment for liver fibrosis. Their role in the vitamin A metabolism and the exceptionally high Raman cross section of retinyl compounds make CARS the ideal tool for this otherwise challenging task. Further details can be found in the article by Marko Rodewald, Hyeonsoo Bae, Sophie Huschke, Tobias Meyer‐Zedler, Michael Schmitt, Adrian Tibor Press, Stephanie Schubert, Michael Bauer, and Jürgen Popp ( e202100040 ).