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Author(s) -
Subramanian Kaushikaram,
Petzold Heike,
Seelbinder Benjamin,
Hersemann Lena,
Nüsslein Ina,
Kreysing Moritz
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202170013
Subject(s) - transparency (behavior) , microscopy , microscope , light scattering , biology , selection (genetic algorithm) , optics , scattering , computer science , physics , artificial intelligence , computer security
Biological cells are highly light scattering, largely precluding the optical access of light microscopes into living tissues. Using a scheme of mutation and high throughput optical selection, the authors present the directed evolution of mammalian cells towards increased transparency. The evolved cells replicate and reflect a physiological state, while showing strongly reduced light scattering, which motivates the authors to propose the generation of genetically enhanced, optically superior tissues (GHOSTs) to advance life microscopy. Further details can be found in the article by Kaushikaram Subramanian, Heike Petzold, Benjamin Seelbinder, LenaHersemann, Ina Nüsslein, and Moritz Kreysing. ( e202000457 ).