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Author(s) -
Lazniewska Joanna,
Darby Jack R. T.,
Holman Stacey L.,
Sorvina Alexandra,
Plush Sally E.,
Massi Massimiliano,
Brooks Doug A.,
Morrison Janna L.
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202170011
Subject(s) - fetus , adipose tissue , fetal growth , metabolic activity , biology , confocal microscopy , anatomy , endocrinology , microbiology and biotechnology , andrology , physiology , pregnancy , medicine , genetics
Sheep models of intrauterine growth restriction (IUGR) were utilised to investigate metabolic changes in fetal perirenal adipose tissue (PAT). Using two‐photon microscopy, a decreased redox ratio was detected in IUGR fat. This was accompanied by changes in lipid droplet morphology, detected by confocal microscopy, and by altered expression of metabolic‐related genes. The results indicate that metabolic imbalance of fetal PAT may increase the chance of survival of growth‐restricted neonates. Further details can be found in the article by Joanna Lazniewska, Jack R. T. Darby, Stacey L. Holman, Alexandra Sorvina, Sally E. Plush, Massimiliano Massi, Doug A. Brooks, and Janna L. Morrison ( e202000322 ).