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Monitoring the extracellular matrix remodeling of high‐grade serous ovarian cancer with nonlinear optical microscopy
Author(s) -
Yan Junshuai,
Zhao Yihua,
Lin Fangrui,
Qu Junle,
Liu Qianyu,
Pan Ying,
Liu Liwei
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000498
Subject(s) - fallopian tube , extracellular matrix , serous fluid , ovary , ovarian cancer , biology , pathology , microbiology and biotechnology , cancer research , medicine , cancer , endocrinology , anatomy
The mortality of high‐grade serous ovarian cancer (HGSOC) accounts for 70% to 80% of all ovarian cancer deaths and overall mortality rate has not declined in the last decade. Recently, many studies have demonstrated that HGSOC originates from the fallopian tubes. The extracellular matrix (ECM) is present in all tissues, its remodeling and interaction with cells are crucial for regulating cell proliferation, migration, and differentiation. In this paper, we used label‐free nonlinear optical microscopy to image tissues of the fallopian tube and ovary. Combining a set of image processing algorithms, we monitored the remodeling of ECM in the fallopian tube and ovary during the invasion of primary serous fallopian tube tumor into the ovary in microscopic dimension. With this approach, we can obtain physiological information of HGSOC at the early stage, which provided useful data for auxiliary clinical diagnosis.