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Characterizing thrombus with multiple red blood cell compositions by optical coherence tomography attenuation coefficient
Author(s) -
Liu HsiaoChuan,
Abbasi Mehdi,
Ding Yong Hong,
Polley Eric C.,
Fitzgerald Seán,
Kadirvel Ramanathan,
Kallmes David F.,
Brinjikji Waleed,
Urban Matthew W.
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000364
Subject(s) - optical coherence tomography , attenuation , attenuation coefficient , biomedical engineering , medicine , human blood , radiology , nuclear medicine , optics , physics , physiology
Embolectomy is one of the emergency procedures performed to remove emboli. Assessing the composition of human blood clots is an important diagnostic factor and could provide guidance for an appropriate treatment strategy for interventional physicians. Immunostaining has been used to identity compositions of clots as a gold‐standard procedure, but it is time‐consuming and cannot be performed in situ. Here, we proposed that the optical attenuation coefficient of optical coherence tomography (OCT) can be a reliable indicator as a new imaging modality to differentiate clot compositions. Fifteen human blood clots with multiple red blood cell (RBC) compositions from 21% to 95% were prepared using healthy human whole blood. A homogeneous gelatin phantom experiment and numerical simulation based on the Lambert–Beer's law were examined to verify the validity of the attenuation coefficient estimation. The results displayed that optical attenuation coefficients were strongly correlated with RBC compositions. We reported that attenuation coefficients could be a promising biomarker to guide the choice of an appropriate interventional device in a clinical setting and assist in characterizing blood clots.