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Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study
Author(s) -
Ren Wuwei,
DeánBen Xosé Luís,
Augath MarkAurel,
Razansky Daniel
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000293
Subject(s) - magnetic resonance imaging , imaging phantom , biomedical engineering , ultrasound , artifact (error) , materials science , real time mri , computer science , nuclear magnetic resonance , radiology , medicine , computer vision , physics
Optoacoustic tomography (OAT) and magnetic resonance imaging (MRI) provide highly complementary capabilities for anatomical and functional imaging of living organisms. Herein, we investigate on the feasibility of combining both modalities to render concurrent images. This was achieved by introducing a specifically‐designed copper‐shielded spherical ultrasound array into a preclinical MRI scanner. Phantom experiments revealed that the OAT probe caused minimal distortion in the MRI images, while synchronization of the laser and the MRI pulse sequence enabled defining artifact‐free acquisition windows for OAT. Good dynamic OAT contrast from superparamagnetic iron oxide nanoparticles, a commonly used agent for MRI contrast enhancement, was also observed. The hybrid OAT‐MRI system thus provides an excellent platform for cross‐validating functional readings of both modalities. Overall, this initial study serves to establish the technical feasibility of developing a hybrid OAT‐MRI system for biomedical research.