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Assessing the effect of prolonged use of desloratadine on adipose Brillouin shift and composition in rats
Author(s) -
TroyanovaWood Maria,
Gobbell Cassidy,
Meng Zhaokai,
Gasheva Olga,
Gashev Anatoliy,
Yakovlev Vladislav V.
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000269
Subject(s) - adipose tissue , desloratadine , white adipose tissue , endocrinology , medicine , chemistry , antihistamine , pharmacology
Antihistamines, which are commonly used to treat allergic reactions, are known for their side effects, which contribute to weight gain. It is hypothesized that simultaneous Brillouin elastography and Raman spectroscopy can be used to detect changes in adipose tissue associated with a prolonged intake of desloratadine, a commonly used second generation antihistamine. White and brown adipose tissue samples were excised from adult rats following 16 weeks of daily administration of desloratadine. It was found that the prolonged intake of desloratadine leads to an increase in Brillouin shift in both adipose tissue types. Raman spectra indicate that antihistamine use reduces protein‐to‐lipid ratio in brown adipose tissue but not white adipose tissue, indicating the effect on adipose tissue is location‐dependent.