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In vivo dynamic characterization of the human tympanic membrane using pneumatic optical coherence tomography
Author(s) -
Won Jungeun,
Porter Ryan G.,
Novak Michael A.,
Youakim Jon,
Sum Ada,
Barkalifa Ronit,
Aksamitiene Edita,
Zhang Anqi,
Nolan Ryan,
Shelton Ryan,
Boppart Stephen A.
Publication year - 2021
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000215
Subject(s) - eardrum , optical coherence tomography , middle ear , biomedical engineering , ear canal , displacement (psychology) , acoustics , tomography , computer science , materials science , optics , medicine , anatomy , physics , psychology , psychotherapist
Decreased mobility of the human eardrum, the tympanic membrane (TM), is an essential indicator of a prevalent middle ear infection. The current diagnostic method to assess TM mobility is via pneumatic otoscopy, which provides subjective and qualitative information of subtle motion. In this study, a handheld spectral‐domain pneumatic optical coherence tomography system was developed to simultaneously measure the displacement of the TM, air pressure inputs applied to a sealed ear canal, and to perform digital pneumatic otoscopy. A novel approach based on quantitative parameters is presented to characterize spatial and temporal variations of the dynamic TM motion. Furthermore, the TM motions of normal middle ears are compared with those of ears with middle ear infections. The capability of noninvasively measuring the rapid motion of the TM is beneficial to understand the complex dynamics of the human TM, and can ultimately lead to improved diagnosis and management of middle ear infections.