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In vivo noninvasive measurement of spatially resolved corneal elasticity in human eyes using Lamb wave optical coherence elastography
Author(s) -
Jin Zi,
Chen Sisi,
Dai Yingying,
Bao Chenhong,
Ye Shuling,
Zhou Yuheng,
Wang Yiyi,
Huang Shenghai,
Wang Yuanyuan,
Shen Meixiao,
Zhu Dexi,
Lu Fan
Publication year - 2020
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000104
Subject(s) - elasticity (physics) , elastography , optical coherence tomography , cornea , lamb waves , optics , repeatability , biomedical engineering , wave propagation , materials science , ultrasound , acoustics , physics , medicine , mathematics , composite material , statistics
Current elastography techniques are limited in application to accurately assess spatially resolved corneal elasticity in vivo for human eyes. The air‐puff optical coherence elastography (OCE) with an eye motion artifacts correction algorithm is developed to distinguish the in vivo cornea vibration from the eye motion and visualize the Lamb wave propagation clearly in healthy subjects. Based on the Lamb wave model, the phase velocity dispersion curve in the high‐frequency is calculated to obtain spatially resolved corneal elasticity accurately with high repeatability. It is found that the corneal elasticity has regional variations and is correlated with intraocular pressure, which suggests that the method has the potential to provide noninvasive measurement of spatially resolved corneal elasticity in clinical practice.