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Response to comment by Puppels et al. on “A modification for the calculation of water depth profiles in oil‐treated skin by in vivo Raman microscopy”
Author(s) -
Darvin Maxim E.,
Choe Chunsik,
Schleusener Johannes,
Choe Sehyok,
Lademann Jürgen
Publication year - 2020
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000093
Subject(s) - stratum corneum , superposition principle , raman spectroscopy , homogeneous , materials science , microscopy , in vivo , chemistry , biomedical engineering , analytical chemistry (journal) , chromatography , optics , pathology , mathematics , biology , medicine , mathematical analysis , physics , microbiology and biotechnology , combinatorics
The presence of penetrated oils in the stratum corneum (SC), oil‐induced occlusion of the SC and formation of occluding homogeneous film on the skin surface are discussed in relation to their influence on results of water profile calculations using conventional and newly proposed extended methods. It is shown that the conventional method does not determine the water profiles in treated skin correctly due to the superposition of Raman bands of SC's proteins and penetrated and remnant oils.