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Jones matrix‐based speckle‐decorrelation angiography using polarization‐sensitive optical coherence tomography
Author(s) -
Gong Peijun,
Li Qingyun,
Wang Qiang,
Karnowski Karol,
Sampson David D.
Publication year - 2020
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.202000007
Subject(s) - speckle pattern , decorrelation , optical coherence tomography , optical coherence tomography angiography , scanner , optics , image quality , angiography , computer science , physics , biomedical engineering , computer vision , medicine , radiology , image (mathematics)
We show that polarization‐sensitive optical coherence tomography angiography (PS‐OCTA) based on full Jones matrix assessment of speckle decorrelation offers improved contrast and depth of vessel imaging over conventional OCTA. We determine how best to combine the individual Jones matrix elements and compare the resulting image quality to that of a conventional OCT scanner by co‐locating and imaging the same skin locations with closely matched scanning setups. Vessel projection images from finger and forearm skin demonstrate the benefits of Jones matrix‐based PS‐OCTA. Our study provides a promising starting point and a useful reference for future pre‐clinical and clinical applications of Jones matrix‐based PS‐OCTA.