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Front Cover: Highly hydrophilic cationic gold nanorods stabilized by novel quaternary ammonium surfactant with negligible cytotoxicity (J. Biophotonics 12/2019)
Author(s) -
Salajkova Sarka,
Sramek Michal,
Malinak David,
Havel Filip,
Musilek Kamil,
Benkova Marketa,
Soukup Ondrej,
Vasicova Pavla,
Prchal Lukas,
Dolezal Rafael,
Hodny Zdenek,
Bartek Jiri,
Zarska Monika,
Kuca Kamil
Publication year - 2019
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201970041
Subject(s) - cationic polymerization , nanorod , cytotoxicity , ethylene glycol , photothermal therapy , pulmonary surfactant , ammonium , chemistry , combinatorial chemistry , materials science , nanotechnology , organic chemistry , biochemistry , in vitro
Cationic gold nanorods stabilized by quaternary ammonium salts (QAS) are a promising tool for photothermal destruction of cancer cells. However, cytotoxicity of the alkanethiol‐QAS limits their medical applications. A novel design of cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain significantly reduces the compound cytotoxicity in the free state while allowing the preparation of stable nanorods with high cellular uptake and lysosomal localization. Further details can be found in the article by Sarka Salajkova, Michal Sramek, David Malinak, et al. ( e201900024 ).