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Front Cover: Widefield fluorescence lifetime imaging of protoporphyrin IX for fluorescence‐guided neurosurgery: An ex vivo feasibility study (J. Biophotonics 6/2019)
Publication year - 2019
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201970018
Subject(s) - ex vivo , biophotonics , protoporphyrin ix , fluorescence lifetime imaging microscopy , fluorescence , materials science , optics , biomedical engineering , in vivo , laser , medicine , physics , biology , microbiology and biotechnology
To optimize the resection of gliomas during neurosurgery we present an imaging system capable of wide field fluorescence lifetime mapping with 11 mm field of view and 250 mm working distance. Based on a time of flight dual‐tap CMOS camera and a modulated laser at 405 nm we show unobserved quenching effects in tissue phantoms and demonstrate life‐time imaging on 5‐ALA labeled human ex vivo brain tumor samples. Further details can be found in the article by Mikael T. Erkkilä, Bianca Bauer, Nancy Hecker‐Denschlag, et al. ( e201800378 ).