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Inside Front Cover: Dynamic visualization of the recovery of mouse hepatobiliary metabolism to acetaminophen‐overdose damage (J. Biophotonics 3/2019)
Publication year - 2019
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201970004
Subject(s) - acetaminophen , metabolism , front cover , in vivo , intravital microscopy , chemistry , drug metabolism , pharmacology , biochemistry , biology , cover (algebra) , mechanical engineering , engineering , microbiology and biotechnology
In this work, intravital multiphoton microscopy was used to image and quantify hepatobiliary metabolism of 6‐carboxyfluorescein diacetate in the recovery of acetaminophen‐overdose mice. It was found that the excretion of the probe molecule was time‐dependent and hepatobiliary metabolism is higher in recovered mice, suggesting that newly regenerated hepatocytes have higher metabolic capabilities. This approach may be further developed applied to studying drug‐induced hepatotoxicity in vivo. Further details can be found in the article by Feng‐Chieh Li, Sheng‐Lin Lee, Hung‐Ming Lin, et al. ( e201800296 ).