Premium
Handheld volumetric manual compression‐based quantitative microelastography
Author(s) -
Fang Qi,
Frewer Luke,
Zilkens Renate,
Krajancich Brooke,
Curatolo Andrea,
Chin Lixin,
Foo Ken Y.,
Lakhiani Devina D.,
Sanderson Rowan W.,
Wijesinghe Philip,
Anstie James D.,
Dessauvagie Benjamin F.,
Latham Bruce,
Saunders Christobel M.,
Kennedy Brendan F.
Publication year - 2020
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201960196
Subject(s) - imaging phantom , biomedical engineering , actuator , computer science , mobile device , elastography , compression (physics) , cadaveric spasm , computer vision , materials science , artificial intelligence , acoustics , surgery , medicine , radiology , ultrasound , physics , composite material , operating system
Compression optical coherence elastography (OCE) typically requires a mechanical actuator to impart a controlled uniform strain to the sample. However, for handheld scanning, this adds complexity to the design of the probe and the actuator stroke limits the amount of strain that can be applied. In this work, we present a new volumetric imaging approach that utilizes bidirectional manual compression via the natural motion of the user's hand to induce strain to the sample, realizing compact, actuator‐free, handheld compression OCE. In this way, we are able to demonstrate rapid acquisition of three‐dimensional quantitative microelastography (QME) datasets of a tissue volume (6 × 6 × 1 mm 3 ) in 3.4 seconds. We characterize the elasticity sensitivity of this freehand manual compression approach using a homogeneous silicone phantom and demonstrate comparable performance to a benchtop mounted, actuator‐based approach. In addition, we demonstrate handheld volumetric manual compression‐based QME on a tissue‐mimicking phantom with an embedded stiff inclusion and on freshly excised human breast specimens from both mastectomy and wide local excision (WLE) surgeries. Tissue results are coregistered with postoperative histology, verifying the capability of our approach to measure the elasticity of tissue and to distinguish stiff tumor from surrounding soft benign tissue.