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Polarized light therapy: Shining a light on the mechanism underlying its immunomodulatory effects
Author(s) -
Feehan Jack,
Tripodi Nicholas,
Fraser Sarah,
Mikkelsen Kathleen,
Thewlis April,
Kiatos Dimitrios,
Husaric Maja,
Apostolopoulos Vasso
Publication year - 2020
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201960177
Subject(s) - downregulation and upregulation , u937 cell , cd86 , monocyte , inflammation , immune system , cd14 , microbiology and biotechnology , receptor , immunology , cancer research , biology , medicine , cell culture , gene , t cell , biochemistry , genetics
This study investigates the immunomodulatory effects of polychromatic polarized light therapy (PLT) on human monocyte cells. While there is some evidence demonstrating a clinical effect in the treatment of certain conditions, there is little research into its mechanism of action. Herein, U937 monocyte cells were cultured and exposed to PLT. The cells were then analyzed for change in expression of genes and cell surface markers relating to inflammation. It was noted that 6 hours of PLT reduced the expression of the CD14, MHC I and CD11b receptors, and increased the expression of CD86. It was also shown that PLT caused downregulation of the genes IL1B, CCL2, NLRP3 and NOD1, and upregulation of NFKBIA and TLR9. These findings imply that PLT has the capacity for immunomodulation in human immune cells, possibly exerting an anti‐inflammatory effect.