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A robust ex vivo method to evaluate the diffusion properties of agents in biological tissues
Author(s) -
Carneiro Isa,
Carvalho Sónia,
Henrique Rui,
Oliveira Luís M.,
Tuchin Valery V.
Publication year - 2019
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201800333
Subject(s) - ex vivo , glycerol , robustness (evolution) , in vivo , materials science , biomedical engineering , diffusion , transmittance , chemistry , biochemistry , biology , optoelectronics , physics , thermodynamics , microbiology and biotechnology , medicine , gene
A robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Amongst other results, the diffusion coefficient of glycerol in colorectal muscle was estimated with a value of 3.3 × 10 −7 cm 2 /s. Due to the robustness and simplicity of the method, it can be used in other fields of biomedical engineering, namely in organ cryoprotection and food industry.