Premium
Handheld multi‐modal imaging for point‐of‐care skin diagnosis based on akinetic integrated optics optical coherence tomography
Author(s) -
SanchoDurá Juan,
Zinoviev Kirill,
LloretSoler Juan,
RubioGuviernau Jose Luis,
MargalloBalbás Eduardo,
Drexler Wolfgang
Publication year - 2018
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201800193
Subject(s) - optical coherence tomography , miniaturization , scanner , medical imaging , footprint , biomedical engineering , optics , materials science , computer science , medicine , artificial intelligence , physics , nanotechnology , paleontology , biology
A handheld skin imaging system with joint optical coherence tomography (OCT) at 1300 nm and digital epiluminescence microscopy (EM) is presented. The 2 modalities are physically co‐registered in a common‐path configuration. The instrument is enabled by a dedicated planar lightwave circuit with a footprint of only 1.1 × 19.5 mm 2 that provides akinetic axial OCT scanning at speeds up to 24 kHz. Lateral scanning is implemented through a low‐voltage Micro Electro‐Mechanical System (MEMS) mirror packaged with the axial scanner in a hermetic butterfly module. The OCT system, with a volume of only 80 × 27 × 14 mm 3 , achieves an isotropic resolution of ~11 μm in tissue, −93 dB sensitivity, 12 mm lateral field of view, and an axial scanning range of 2.8 mm in air. The complete battery‐powered device has a weight of 3 kg in a tablet format, enabling point‐of‐care use cases. This work shows that integration of complementary imaging modalities through miniaturization technology results in clinically valuable instruments supporting a patient‐centered diagnostic imaging workflow.