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Assessment of the influence of viscoelasticity of cornea in animal ex vivo model using air‐puff optical coherence tomography and corneal hysteresis
Author(s) -
Maczynska Ewa,
Karnowski Karol,
Szulzycki Krzysztof,
Malinowska Monika,
Dolezyczek Hubert,
Cichanski Artur,
Wojtkowski Maciej,
Kaluzny Bartlomiej,
Grulkowski Ireneusz
Publication year - 2019
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201800154
Subject(s) - optical coherence tomography , cornea , materials science , ex vivo , optics , biomedical engineering , viscoelasticity , intraocular pressure , in vivo , ophthalmology , medicine , physics , composite material , biology , microbiology and biotechnology
Application of the air‐puff swept source optical coherence tomography (SS‐OCT) instrument to determine the influence of viscoelasticity on the relation between overall the air‐puff force and corneal apex displacement of porcine corneas ex vivo is demonstrated. Simultaneous recording of time‐evolution of the tissue displacement and air pulse stimulus allows obtaining valuable information related in part to the mechanical properties of the cornea. A novel approach based on quantitative analysis of the corneal hysteresis of OCT data is presented. The corneal response to the air pulse is assessed for different well‐controlled intraocular pressure (IOP) levels and for the progression of cross‐linking‐induced stiffness of the cornea. Micrometer resolution, fast acquisition and noncontact character of the air‐puff SS‐OCT measurements have potential to improve the in vivo assessment of mechanical properties of the human corneas.