Premium
Triphenylphosphonium cation: A valuable functional group for antimicrobial photodynamic therapy
Author(s) -
BresolíObach Roger,
Gispert Ignacio,
Peña Diego G.,
Boga Sonia,
Gulias Óscar,
Agut Montserrat,
Vázquez M. Eugenio,
ll Santi
Publication year - 2018
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201800054
Subject(s) - antimicrobial , enterococcus faecalis , photodynamic therapy , bacteria , cationic polymerization , microbiology and biotechnology , staphylococcus aureus , chemistry , enterococcus , combinatorial chemistry , biology , antibiotics , organic chemistry , genetics
Light‐mediated killing of pathogens by cationic photosensitisers is a promising antimicrobial approach that avoids the development of resistance inherent to the use of antimicrobials. In this study, we demonstrate that modification of different photosensitisers with the triphenylphosphonium cation yields derivatives with excellent photoantimicrobial activity against Gram‐positive bacteria (ie, Staphylococcus aureus and Enterococcus faecalis ). Thus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram‐positive bacteria in the presence of Gram‐negative species.