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Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways
Author(s) -
Migliario Mario,
Sabbatini Maurizio,
Mortellaro Carmen,
Renò Filippo
Publication year - 2018
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201800025
Subject(s) - biostimulation , photobiology , laser , low level laser therapy , signal transduction , biophysics , reactive oxygen species , cell growth , microbiology and biotechnology , materials science , chemistry , biomedical engineering , medicine , laser therapy , biology , optics , biochemistry , botany , genetics , physics , bacteria , bioremediation
Lasers devices are widely used in various medical fields (eg, surgery, dermatology, dentistry, rehabilitative medicine, etc.) for different applications, ranging from surgical ablation of tissues to biostimulation and pain relief. Laser is an electromagnetic radiation, which effects on biological tissues strongly depends on a number of physical parameters. Laser wavelength, energy output, irradiation time and modality, temperature and tissue penetration properties have to be set up according to the clinical target tissue and the desired effect. A less than optimal operational settings, in fact, could result in a null or even lethal effect. According to the first law of photobiology, light absorption requires the presence of a specific photoacceptor that after excitation could induce the activation of downstream signaling pathways. Low‐level lasers operating in the red/near infrared portion of the light spectra are generally used for biostimulation purposes, a particular therapeutic application based on the radiant energy ability to induce nonthermal responses in living cells. Biostimulation process generally promotes cell survival and proliferation. Emerging evidences support a low‐level laser stimulation mediated increase in “good” reactive oxygen species, able to activate redox sensitive signal transduction pathways such as Nrf‐2, NF‐kB, ERK which act as key redox checkpoints.