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Photodynamic opening of the blood‐brain barrier and pathways of brain clearing
Author(s) -
SemyachkinaGlushkovskaya Oxana,
Chehonin Vladimir,
Borisova Ekaterina,
Fedosov Ivan,
Namykin Anton,
Abdurashitov Arkady,
Shirokov Alexander,
Khlebtsov Boris,
Lyubun Yelena,
Navolokin Nikita,
Ulanova Mariya,
Shushunova Natalia,
Khorovodov Alexander,
Agranovich Ilana,
Bodrova Anastasia,
Sagatova Madina,
Shareef Ali Esmat,
Saranceva Elena,
Iskra Tatyana,
Dvoryatkina Mariya,
Zhinchenko Ekaterina,
Sindeeva Olga,
Tuchin Valery,
Kurths Jurgen
Publication year - 2018
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201700287
Subject(s) - photodynamic therapy , blood–brain barrier , photosensitizer , medicine , colloidal gold , biomedical engineering , pathology , central nervous system , chemistry , materials science , nanotechnology , nanoparticle , organic chemistry
A new application of the photodynamic treatment (PDT) is presented for the opening of blood‐brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate 2 pathways for the brain clearing: (1) using PDT‐opening of BBB and intravenous injection of FITC‐dextran we showed a clearance of this tracer via the meningeal lymphatic system in the subdural space; (2) using optical coherence tomography and intraparenchymal injection of gold nanorods, we observed their clearance through the exit gate of cerebral spinal fluid from the brain into the deep cervical lymph node, where the gold nanorods were accumulated. These data contribute to a better understanding of the cerebrovascular effects of PDT and shed light on mechanisms, underlying brain clearing after PDT‐related opening of BBB, including clearance from nanoparticles as drug carriers.