Premium
Reconnectable fiberscopes for chronic in vivo deep‐brain imaging
Author(s) -
Pochechuev M. S.,
Fedotov I. V.,
Ivashkina O. I.,
Roshchina M. A.,
Meshchankin D.V.,
SidorovBiryukov D. A.,
Fedotov A. B.,
Anokhin K. V.,
Zheltikov A. M.
Publication year - 2018
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201700106
Subject(s) - in vivo , neuroimaging , optogenetics , neuroscience , fiberscope , calcium imaging , optical imaging , preclinical imaging , biomedical engineering , medicine , biology , calcium , surgery , microbiology and biotechnology , optics , physics
Reconnectable bundles consisting of thousands of optical fibers are shown to enable high‐quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of this fiberscope as a powerful tool for chronic in vivo neuroimaging using genetically encoded calcium indicators, neuronal activity markers as well as axon growth regulators and brain‐specific protein drivers in deep regions of live brain.