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Cover Picture: Wavelength‐Modulated Differential Photoacoustic Spectroscopy (WM‐DPAS) for noninvasive early cancer detection and tissue hypoxia monitoring (J. Biophotonics 4/2016)
Publication year - 2016
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201670040
Subject(s) - biophotonics , photoacoustic imaging in biomedicine , biomedical engineering , medicine , computer science , pathology , physics , optics , laser
Wavelength‐Modulated Differential Photoacoustic Imaging (WM‐DPAI) is a modality with optimal sensitivity and specificity to oxy‐ and deoxy‐hemoglobin. Top images are from an in‐vitro plastisol phantom with three sheep blood sources (A‐C) of decreasing oxysaturation levels. Bottom images are those of an in‐vivo rat thigh injected with a subcutaneous FaDU tumor. Compared to the single‐ended 808nm PA images (left), the 680/808nm differential images (right) exhibit superior specificity to chromophore oxysaturation level. Further details can be found in the article by Sung soo (Sean) Choi et al. on pp. 388–395 .