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Effective delivery of porphyrazine photosensitizers to cancer cells by polymer brush nanocontainers
Author(s) -
Shilyagitalia Y.,
Peskova Ni.,
Lermontova Svetlana A.,
Brilkina Anna A.,
Vodeneev Vladimir A.,
Yakimansky Alexander V.,
Klapshina Larisa G.,
Balalaeva Irina V.
Publication year - 2017
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201600212
Subject(s) - photosensitizer , amphiphile , drug delivery , side chain , polymer , photodynamic therapy , nanoparticle , porphyrin , chemistry , materials science , nanotechnology , polymer chemistry , nuclear chemistry , combinatorial chemistry , copolymer , photochemistry , organic chemistry
Efficient drug delivery can be assigned to tasks that attract the most acute attention of researchers in the field of anticancer drug design. We have reported the first case of using amphiphilic polymer brushes as nanocontainers for photosensitizer delivery to cancer cells. Regular graft‐copolymers of hydrophobic polyimides with hydrophilic polymethacrylic acid side chains were loaded with photosensitive dye tetra(4‐fluorophenyl)tetracyanoporphyrazine (Pz) providing a sufficiently stable homogeneous fraction of fluorescent Pz‐loaded nanoparticles with a size of 100–150 nm. Pz‐loaded polymer brushes were substantially more efficient for Pz delivery into cells compared with other types of particles examined, Pz‐polyethyleneglycol and Pz‐methylcellulose. In vivo , an efficient Pz delivery to tumor can also be expected since the Pz‐PB particle size is in the optimal range for passive targeting. Pz‐PB showed pronounced photodynamic activity, while, that is important, in the absence of irradiation the PB carrier itself was significantly less toxic than the dye itself.Summing up, water‐soluble polymer brushes with polyimide backbones and polymethacrylic acid side chains can be regarded as a novel type of nanocontainers providing efficient intracellular drug delivery for photodynamic therapy of cancers.