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A method to study the hemodynamics of chicken embryo's aortic arches using optical coherence tomography
Author(s) -
Ko Zhen Yu Gordon,
Mehta Kalpesh,
Jamil Muhammad,
Yap Choon Hwai,
Chen Nanguang
Publication year - 2017
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201600119
Subject(s) - optical coherence tomography , aortic arch , hemodynamics , embryo , blood flow , high resolution , embryogenesis , medicine , anatomy , aorta , biology , cardiology , radiology , microbiology and biotechnology , remote sensing , geology
Congenital cardiovascular defects are the leading cause of birth defect related death. It has been hypothesized that fluid mechanical forces of embryonic blood flow affect cardiovascular development and play a role in congenital malformations. Studies in small animal embryos can improve our understanding of congenital malformations and can lead to better treatment. We present a feasibility study in which high‐resolution optical coherence tomography (OCT) and computational fluid dynamics (CFD) are combined to provide quantitative analysis of the embryonic flow mechanics and the associated anatomy in a small animal model.