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Synthesis of a poly(ethylene glycol) galloyl sensitizer tip for an ’all‐in‐one' photodynamic device
Author(s) -
Ghogare Ashwini A.,
Greer Alexander
Publication year - 2016
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201600013
Subject(s) - ethylene glycol , photodynamic therapy , polyvinyl alcohol , chemistry , materials science , solubility , combinatorial chemistry , nanotechnology , chemical engineering , polymer chemistry , photochemistry , organic chemistry , engineering
This paper describes the synthesis of a specialized silica tip for an optical fiber device capable of delivering all components necessary for photodynamic therapy. Oxygen, light and a cleavable tripolyethylene glycol (PEG)‐galloyl pheophorbide sensitizer are simultaneously delivered by the silica tip, where the tip was synthesized in six steps. A comparison of synthetic steps to reach PEGylated sensitizers bound to fluorinated silica and a previously reported Teflon/polyvinyl alcohol (PVA) nanocomposite ( Ghosh , G. et al. J. Phys. Chem. B 2015 , 119 , 4155 – 4164 ) was made. The hydrolytic stability of the attached PEGs and the extent to which the PEG groups enhance solubility will also be discussed. The new triPEG‐galloyl sensitizer has the potential for use in intraoperative pointsource photodynamic therapy which aims for precision treatment of residual disease.Schematic of the synthesis of a photoactive silica surface. It is composed of fluorinated silica connected to a photo‐releasable sensitizer with short‐chain PEGs.