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Cover Picture: Label‐free, zeptomole cancer biomarker detection by surface‐enhanced fluorescence on nanoporous gold disk plasmonic nanoparticles (J. Biophotonics 10/2015)
Publication year - 2015
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201570100
Subject(s) - biophotonics , nanoporous , fluorophore , nanotechnology , fluorescence , colloidal gold , plasmon , biomarker , cover (algebra) , nanoparticle , materials science , chemistry , physics , optics , optoelectronics , photonics , mechanical engineering , engineering , biochemistry
The enhanced fluorescence signals on nanoporous gold disk (NPGD) nanoparticles is showcased for reducing detection limits for biomolecular targets. The hairpin DNA probe features a Cy3 fluorophore on the 3'‐end and a sulfur on the 5'‐end for strong binding to NPGDs. With the hybridization of the breast cancer DNA biomarker, the Cy3 end is positioned advantageously to experience surface‐enhanced fluorescence on the NPGD surface, resulting in an effectual sensing mechanism. Further details can be found in the article by Greggy M. Santos et al. on pp. 855–863 .