Premium
Cover Picture: Raman spectroscopy of blood serum for Alzheimer's disease diagnostics: specificity relative to other types of dementia (J. Biophotonics 7/2015)
Publication year - 2015
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201570070
Subject(s) - dementia , biophotonics , raman spectroscopy , alzheimer's disease , neurology , differential diagnosis , medicine , disease , computer science , cover (algebra) , artificial intelligence , computational biology , neuroscience , pathology , psychology , physics , psychiatry , biology , optics , laser , mechanical engineering , engineering
The key moment for efficiently and accurately diagnosing dementia occurs during the early stages. This is particularly true for Alzheimer's disease (AD). In this proof‐of‐concept study, we applied near infrared (NIR) Raman microspectroscopy of blood serum together with advanced multivariate statistics for the selective identification of AD. We analyzed data from 20 AD patients, 18 patients with other neurodegenerative dementias (OD) and 10 healthy control (HC) subjects. NIR Raman microspectroscopy differentiated patients with more than 95% sensitivity and specificity. We demonstrated the high discriminative power of artificial neural network (ANN) classification models, thus revealing the high potential of this developed methodology for the differential diagnosis of AD. Raman spectroscopic, blood‐based tests may aid clinical assessments for the effective and accurate differential diagnosis of AD, decrease the labor, time and cost of diagnosis, and be useful for screening patient populations for AD development and progression. (Picture: E. Ryzhikova et al., pp 584–596 in this issue) Credits: Dr. Aliaksandra Sikirzhytskaya