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Kinetic analysis of nanoparticle‐protein interactions using a plasmon waveguide resonance
Author(s) -
Bahrami Farshid,
Maisonneuve Mathieu,
Meunier Michel,
Montazeri Arthur O.,
Kim Yujin,
Kherani Nazir P.,
Aitchison J. Stewart,
Mojahedi Mo
Publication year - 2017
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201500267
Subject(s) - surface plasmon resonance , nanoparticle , materials science , surface plasmon , spectroscopy , polarization (electrochemistry) , mesoscopic physics , refractive index , streptavidin , colloidal gold , nanophotonics , schematic , nanotechnology , optoelectronics , plasmon , optics , chemistry , biotin , electronic engineering , physics , biochemistry , quantum mechanics , engineering
A plasmon waveguide resonance (PWR) sensor is proposed for studying the interaction between gold nanoparticles and proteins. The ability of the PWR sensor to operate in both TM and TE Polarizations, i.e. its polarization diversity, facilitates the simultaneous spectroscopy of the nanoparticles surface reactions using both polarizations. The response of each polarization to streptavidin‐biotin binding at the surface of gold nanoparticles is investigated in real time. Finally, using the principles of multimode spectroscopy, the nanoparticle's surface reactions are decoupled from the bulk solution refractive index variations.Schematic diagram of the NP‐modified PWR sensor