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A comparative evaluation of diffuse reflectance and Raman spectroscopy in the detection of cervical cancer
Author(s) -
Shaikh Rubina,
Prabitha Vasumathi G.,
Dora Tapas Kumar,
Chopra Supriya,
Maheshwari Amita,
Deodhar Kedar,
Rekhi Bharat,
Sukumar Nita,
Krishna C. Murali,
Subhash Narayanan
Publication year - 2017
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201500248
Subject(s) - diffuse reflectance infrared fourier transform , medicine , linear discriminant analysis , cervix , raman spectroscopy , principal component analysis , nuclear medicine , cervical cancer , cancer , artificial intelligence , chemistry , optics , computer science , biochemistry , physics , photocatalysis , catalysis
Optical spectroscopic techniques show improved diagnostic accuracy for non‐invasive detection of cervical cancers. In this study, sensitivity and specificity of two in vivo modalities, i.e diffuse reflectance spectroscopy (DRS) and Raman spectroscopy (RS), were compared by utilizing spectra recorded from the same sites (67 tumor (T), 22 normal cervix (C), and 57 normal vagina (V)). Data was analysed using principal component – linear discriminant analysis (PC‐LDA), and validated using leave‐one‐out‐cross‐validation (LOOCV). Sensitivity, specificity, positive predictive value and negative predictive value for classification between normal (N) and tumor (T) sites were 91%, 96%, 95% and 93%, respectively for RS and 85%, 95%, 93% and 88%, respectively for DRS. Even though DRS revealed slightly lower diagnostic accuracies, owing to its lower cost and portability, it was found to be more suited for cervical cancer screening in low resource settings. On the other hand, RS based devices could be ideal for screening patients with centralised facilities in developing countries.