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Polarimetric assessment of healthy and radiofrequency ablated porcine myocardial tissue
Author(s) -
Ahmad Iftikhar,
Gribble Adam,
Ikram Masroor,
Pop Mihaela,
Vitkin Alex
Publication year - 2016
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201500184
Subject(s) - coagulative necrosis , lesion , depolarization , radiofrequency ablation , ablation , polarimetry , medicine , anatomy , pathology , optics , scattering , physics
Radiofrequency (RF) ablation offers a potential treatment for cardiac arrhythmia, where properly titrated energy delivered at critical sites can destroy arrhythmogenic foci. The resulting ablation lesion typically consists of a core (coagulative necrosis) surrounded by a rim of mixed viable and non‐viable cells. The extent of the RF lesion is difficult to delineate with current imaging techniques. Here, we explore polarization signatures of ten ex‐vivo samples from untreated ( n = 5) and RF ablated porcine hearts ( n = 5), in backscattered geometry through Mueller matrix polarimetry. Significant differences ( p < 0.01) in depolarization, Δ T , were observed between the healthy, RF ablated and rim regions. Linear retardance, δ, was significantly lower in the core and rim regions compared to healthy regions ( p < 0.05). The results demonstrate a novel application of polarimetry, namely the characterization of RF ablation extent in myocardium, including the visualization of the important lesion rim region.White light photo (top) of porcine myocardium tissue with radiofrequency ablation lesion and corresponding depolarization map (bottom). Depolarization is useful for visualizing the lesion core and rim.