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Raman spectroscopy as a diagnostic tool for monitoring acute nephritis
Author(s) -
Li Jingting,
Du Yong,
Qi Ji,
Sneha Ravikumar,
Chang Anthony,
Mohan Chandra,
Shih WeiChuan
Publication year - 2016
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201500109
Subject(s) - nephritis , medicine , disease , raman spectroscopy , kidney disease , pathology , intensive care medicine , optics , physics
Both acute nephritis and chronic nephritis account for substantial morbidity and mortality worldwide, partly due to the lack of reliable tools for detecting disease early and monitoring its progression non‐invasively. In this work, Raman spectroscopy coupled with multivariate analysis are employed for the first time to study the accelerated progression of nephritis in anti‐GBM mouse model. Preliminary results show up to 98% discriminant accuracy for the severe and midly diseased and the healthy among two strains of mice with different susceptibility to acute glomerulonephritis. This technique has the potential for non‐invasive or minimally‐invasive early diagnosis, prognosis, and monitoring of renal disease progression.