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Ex vivo investigations on the potential of optical coherence tomography (OCT) as a diagnostic tool for reproductive medicine in a bovine model
Author(s) -
Trottmann Matthias,
Kölle Sabine,
Leeb Regina,
Doering Daniel,
Reese Sven,
Stief Christian G.,
Dulohery Kate,
Leavy Myles,
Kuznetsova Julia,
Homann Christian,
Sroka Ronald
Publication year - 2016
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201500009
Subject(s) - optical coherence tomography , ex vivo , medical imaging , infertility , preclinical imaging , pathology , visualization , tomography , biology , biomedical engineering , in vivo , medical physics , medicine , anatomy , radiology , computer science , artificial intelligence , pregnancy , genetics , microbiology and biotechnology
Routine infertility investigations in the male and female include imaging techniques such as ultrasonography and endoscopy (fertiloscopy). However, these techniques lack the resolution to localize vital sperm or to reveal detailed morphological analysis of the oviduct which is often the cause of infertility in females. Therefore we set out to evaluate the efficiency of optical coherence tomography (OCT) as a diagnostic imaging tool for micron‐scale visualization of the male and female genital tract. Using the bovine as a model, the optical features of the Telesto TM , Ganymede TM (both Thorlabs) and Niris TM (Imalux) OCT imaging systems were compared.Comparative visualization of ex vivo bovine testicular tissue by the Telesto TM microscopic optical coherence tomography system (left) and corresponding H&E staining (right).