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The effect of geometry on tumor thermal profile and its use in tumor functional state estimation
Author(s) -
Tepper Michal,
Shoval Asaf,
Gannot Israel
Publication year - 2015
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201400005
Subject(s) - in vivo , imaging phantom , correlation , positive correlation , tumor cells , thermal , chemistry , biomedical engineering , pathology , biology , cancer research , nuclear medicine , medicine , mathematics , geometry , thermodynamics , physics , microbiology and biotechnology
Thermal differences between transplanted tumors and tumors in humans prevent the implementation of thermographic methods developed in mice models to human models and vise‐versa. Transplantable tumors tend to have an extruding shape, which may affect the thermal patterns. This hypothesis was studied in phantom experiments and simulations. A correlation between tumor dimensions and relative temperature was found and used to estimate tumor functional state from previously published in vivo experiments. A correlation was found between temperature differences and tumor growth rates (tumor aggressiveness) and the effect of tumor treatment was demonstrated, showing the potential for in vivo , non‐invasive tumor monitoring. (© 2015 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim)