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Assessing the challenges of Fourier transform infrared spectroscopic analysis of blood serum
Author(s) -
Hughes Caryn,
Brown Michael,
Clemens Graeme,
Henderson Alex,
Monjardez Geraldine,
Clarke Noel W.,
Gardner Peter
Publication year - 2014
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201300167
Subject(s) - infrared , fourier transform , fourier transform infrared spectroscopy , mathematics , physics , optics , mathematical analysis
There are many approaches to measuring the infrared spectrum of a blood serum sample. Naturally, each approach will have both advantages and disadvantages. We report on the progress of the application of infrared spectroscopy in the field of blood serum analysis towards clinical application, with a focus on prostate cancer. In order to perform a high‐powered study with clinical relevance, choosing the most suitable approach must undergo careful consideration. We review the possibilities of using different sample preparation methods and speculate upon the potential pitfalls of both transmission and attenuated total reflectance (ATR) techniques. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)