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Laser exposure of gold nanorods can induce intracellular calcium transients
Author(s) -
Paviolo Chiara,
Haycock John W.,
Cadusch Peter J.,
McArthur Sally L.,
Stoddart Paul R.
Publication year - 2014
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201300043
Subject(s) - nanorod , laser , intracellular , calcium , calcium in biology , materials science , biophysics , nanotechnology , optoelectronics , chemistry , optics , biology , biochemistry , metallurgy , physics
Uncoated and poly(styrene sulphonate) (PSS)‐coated gold nanorods were taken up by NG108‐15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca 2+ transients. The higher Ca 2+ peaks were observed at lower laser doses, with the highest levels obtained at a radiant exposure of 0.33 J/cm 2 . In contrast, the cells without nanoparticles showed a consistently small response, independent of the laser dose. These initial results open up new opportunities for peripheral nerve regeneration treatments and for more efficient optical stimulation techniques. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)