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Effect of photodynamic therapy on the skin using the ultrashort laser ablation
Author(s) -
Nicolodelli Gustavo,
Angarita Dora Patricia Ramírez,
Inada Natalia Mayumi,
Tirapelli Luis Fernando,
Bagnato Vanderlei Salvador
Publication year - 2014
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201300024
Subject(s) - photodynamic therapy , ablation , laser , femtosecond , tumor ablation , penetration (warfare) , biomedical engineering , laser ablation , chemistry , dermatology , materials science , optics , medicine , physics , organic chemistry , operations research , engineering
Photodynamic Therapy (PDT) with 5‐aminolevulinic acid (ALA) is known to be limited for applications in tumours of large volume mainly due to the limited penetration of topical photosensitization. The results show that micro‐holes created using a femtosecond laser before PDT significantly increased the depth of PDT effect in the healthy tissue. The combination of ultrashort laser ablation technique with PDT showed an important scientific breakthrough related to transportation and delivery of drugs into the deeper regions of the tissue. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)