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Estimating the risk of squamous cell cancer induction in skin following nonlinear optical imaging
Author(s) -
Thomas Giju,
Nadiarnykh Oleg,
van Voskuilen Johan,
Hoy Christopher L.,
Gerritsen Hans C.,
Sterenborg Henricus J. C. M.
Publication year - 2014
Publication title -
journal of biophotonics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 66
eISSN - 1864-0648
pISSN - 1864-063X
DOI - 10.1002/jbio.201200207
Subject(s) - skin cancer , pyrimidine dimer , carcinogenesis , laser , basal cell , cancer research , irradiation , cancer , radiation , dna damage , medicine , optics , pathology , chemistry , dna , physics , biochemistry , nuclear physics
High power femto‐second (fs) laser pulses used for in‐vivo nonlinear optical (NLO) imaging can form cyclobutane pyrimidine dimers (CPD) in DNA, which may lead to carcinogenesis via subsequent mutations. Since UV radiation from routine sun exposure is the primary source of CPD lesions, we evaluated the risk of CPD‐related squamous cell carcinoma (SCC) in human skin due to NLO imaging relative to that from sun exposure. We developed a unique cancer risk model expanding previously published estimation of risk from exposure to continuous wave (CW) laser. This new model showed that the increase in CPD‐related SCC in skin from NLO imaging is negligible above that due to regular sun exposure. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)